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Thenge, R. R.
- Taste Masking and Evaluation of Rapid Disintegrating Tablet of Gatifloxacin Sesquihydrate
Authors
1 College of Pharmacy, Malkapur, Dist. – Buldana, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 135-138Abstract
Gatifloxacin Sesquihydrate is a Broad Spectrum Antimicrobial agent active against Gram Positive and Gram Negative Organism. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Gatifloxacin Sesquihydrate using Indion 204, Indion 214, Indion 234, Tulsion 335 (ion exchange resin) as a taste masking agent. X-ray powder diffractometry, FT-IR spectroscopy and differential scanning calorimetry were used to investigate the physical characteristics of the crystals. The tablet was prepared by Wet granulation technique with three super disintegrants e.g. sodium starch glycolate, crosscarmellose sodium and crospovidone. The granules were examined for angle of repose, bulk density, tapped density and hausner’s ratio. The tablets were evaluated for hardness, drug content and friability and disintegration time. The disintegration in oral cavity was also tested and was found to be 22 sec. Also In-Vivo and In-Vitro taste Evaluation of Solid Drug: Resin Complex was carried out.Keywords
Fast Dissolving Tablet, Gatifloxacin Sesquihydrate, Ion Exchange Resin, Super Disintegrants.- Preliminary Phytochemical and Anti-Pyretic Screening of Crude Extract of the Leaf of Clerodendrum colebrookianum
Authors
1 College of Pharmacy, Malkapur, Dist.-Buldana, Maharashtra, IN
2 S.B.College of Pharmacy, Sivakasi, Dist-Virudunagar, 626130 Tamilnadu, IN
3 College of Pharmacy, Malkapur, Dist-Buldana, 443101 Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 191-193Abstract
The current study was focused to evaluate the antipyretic potential of the hexane extract (HECC) and methanol extract (MECC) of the whole plant Clerodendrum colebrookianum (Family: Verbenaceae). HECC and MECC on normal body temperature and yeast - induced pyrexia in albino rats. The whole plant Clerodendrum colebrookianum was collected from Arvind Herbal lab, Rajapalayam and authenticated. The pulverized plant material (1000 gm) was extracted successively with hexane and methanol solvents in a soxhlet apparatus. Adult albino rats of either sex weighing 180 - 200g were taken for the experiment. Yeast suspension (10 ml /kg body wt.) increased rectal temperature after 17 hours of subcutaneous injection. The HECC and MECC at doses of 100mg, 300mg and 500mg / kg body temperature and yeast - provoked elevated temperature in a dose dependent manner. The effect also extended up to 5 hours after the drug administration. The anti-pyretic effect of HECC and MECC was comparable to that of a standard antipyretic agent paracetamol (150 mg / kg body wt, p.o).